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Specifically, Wu et al

The values were calculated as: Experimentally, is calculated from the fluorescence intensity ratio: Where and are the fluorescence ratios under fully reduced and oxidized conditions, and and are the fluorescence intensities at 488 nm in reduced and oxidized states

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Comparable to the observations made in the plasma, the lactate/pyruvate ratio showed a borderline significant increase in the aged hippocampus of both genotypes (Supplementary Fig