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Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia: Carcinogenesis, Mutagenesis, Impairment of Fertility Studies of lidocaine HCl in animals to evaluate the carcinogenic and mutagenic potential or the effect on fertility have not been conducted

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In SPPS, amino acids are assembled one residue at a time on a solid resin, with protecting groups added and removed in carefully controlled cycles