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Although MNX mice are generally healthy and fertile, but, depending on the mtDNAnuclear DNA combination, exhibit different cellular bioenergetics, mitochondrial ROS generation and susceptibility to cardiac stress and atherogenic diet [15,16]

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ROS can be dangerous to cells as well as human organs since they can attack lipids of cell membranes, enzymes, carbohydrates and DNA, leading to oxidative process

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