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Reithmeier showed in 1987 that the structure of another calcium-binding protein, calsequestrin (which binds 40-50 calcium ions and is characterized by high levels of acidic residues), is calcium-sensitive as well, as this protein was rapidly degraded by trypsin in the absence of calcium, but showed remarkable stability in calcium-loaded form (Ohnishi and Reithmeier, 1987)

Wang, J., Li, M., Geng, Z., Khattak, S., Ji, X., Wu, D., & Dang, Y

The mechanism of GLP-1-induced nausea involves central GLP-1R activation in the brainstem, specifically in the area postrema, which is the chemoreceptor trigger zone for vomiting

It replenishes mitochondrial energy in neurons and re-regulates the circadian clock (via SIRT1/CLOCK), normalizing dopamine synthesis in the nucleus accumbens to reduce cravings and withdrawal anxiety

They only show unpublished data