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The results showed that vitamin B complex treatment reduced proinflammatory cytokine expression while increasing anti-inflammatory cytokine expression, and this led to neuroinflammation resolution

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5-Amino-1MQ targets the substrate binding site of NNMT the nicotinamide binding pocket competitively inhibiting nicotinamide methylation with an IC50 of 1.2 M under reference assay conditions

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This means treatment must start with tiny doses, increase slowly, and continue for 3 to 5 years