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The structural data also revealed the molecular mechanism of SAM activation, whereby the Bateman module in the RD acts as an autoinhibitory cap to the CD, and upon binding SAM, undergoes a conformational change relieving the inhibition to allow active site access for catalysis (Supplementary Fig

Both PAD and tTG are active in joints and the intestine, with the latter of these modification proteins being over expressed in the synovium of RA patients suggesting a possible role in disease pathogenesis (Lauzier et al

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In this context, L* represents brightness, a* represents redness, and b* represents yellowness

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