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doi: 10.1016/j.bbrc.2014.04.039

However, long-term use of irreversible MAO inhibitors has been associated with compensatory mechanisms, such as the upregulation of diamine oxidase (DAO), 36 which can limit long-term efficacy

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M.SchwiertzA.EndresK

Additionally, certain bacteria have the ability to convert TMA and TMAO into DMA and formaldehyde through trimethylamine dehydrogenase (TMADH) and TMAO demethylase