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Acknowledgements We would like to acknowledge Professor Gordon Stamp (University College London/The Francis Crick Institute) for providing evaluation of cellularity of human tissues samples used for metabolomics analysis in this study

The subjects continued to eat normally and adhered to a resistance-training regimen of progressive overload (4 days per week, divided between upper and lower body)

The upregulation of N-cadherin and stem cell marker ABCB5 also contributes to EMT [11]

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Unlike other hair removal techniques, laser removal kills the roots of the hair follicles in the targeted area