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When ZFN binds to the target gene, FokI will cut the DNA to form a double-strand break, thereby triggering the cells repair mechanism and achieving gene editing (Fig

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Collectively, gout has been redefined at the levels of the subjects affected, diagnosis, treatment, and definition of appropriate therapeutic targets and outcomes

The primary metabolite M1 had a short half-life (approximately 3 hours) whereas the secondary metabolite M3 eliminated at a slower rate (half-life approximately 13.5 hours)

Animals treated with NMN received a single injection at the time of chemotherapy, in addition to ongoing treatment with NMN in drinking water at 2 g/L, which started 72 h prior to chemotherapy and continued until the end of all experiments