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During niacin treatment, fasting glucose, insulin and HOMA1-IR (insulin resistance score based on blood glucose and insulin) increased in some individuals up to 1.9-fold after niacin dose of 500 mg, suggesting increased insulin resistance (Fig

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doi: 10.1016/j.cell.2023.02.021 53 AlonsoRFlamentHLemoineSSedlikCBottassoEPguilletIet al

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Several investigational agents capable of inhibiting NLRP3 activation, such as tranilast, 354 dapansutrile (OLT1177, selective inhibitor), 354 and thiazolo-alkenyl sulfonylurea derivative 7, 355 are also being considered for COVID-CS treatment as reviewed by Freeman and Swartz