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The blockage of Notch signalling promoted the generation of polymorphonuclear myeloid-derived suppressor cells with lower immunosuppression

Foil covers were changed each time

Specifically, if administered by injection, redness and swelling may occur at the injection site

A previous study demonstrated that in ASS1-deficient myxofibrosarcoma, ASS1 re-expression inhibited tumor growth by inhibiting tumor angiogenesis and inducing G1 phase arrest, indicating that ASS1 was a new tumor suppressor (Huang et al., 2013)

In heterogeneous tumor environments, achieving selective targeting of mutant p53 cells without damaging wild-type p53-dependent normal cells is a major challenge, mainly for the following reasons: some drugs targeting mutant p53 may also be toxic to wild-type p53 cells, and the complex tumor microenvironment may affect the efficacy of drugs