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Abbreviations BBB: Blood brain barrier ATP: Adenosine triphosphate IL-1: Interleukin-1 MAPK: Mitogen-activated protein kinase HT: Hemorrhagic transformation ROS: Reactive oxygen species RNS: Reactive nitrogen species GSH: Glutathione GSSH: Glutathione disulfide REDOX: Reductionoxidation r-tPA: Recombinant tissue-type plasminogen activator GA: Gallic acid OECs: Overgrown endothelial cells NOX2: NADPH oxidase 2 GLP-1R: Glucagon-like peptide-1 receptor GM130: Golgi matrix protein 130 Ce/Zeo-NMs cerium: (Ce)-doped Linde Type A (LTA) zeolite-based nanomaterials NPs: Nanoparticles uPA: Urokinase-type plasminogen activator BPNs: Black phosphorus nanosheets SAB: Salvianolic acid B AST IV: Astragaloside IV PNS: Saponins of notoginseng VEGF: Vascular endothelial growth factor References Ehrlich P

Proc Natl Acad Sci USA 101 , 77117715, (2004)

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