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[DOI] [PMC free article] [PubMed] [Google Scholar] 187.Burra P, Bizzaro D, Gonta A, Shalaby S, Gambato M, Morelli MC, et al

Similarly, studies have shown that mast cell-derived tryptase can degrade cartilage ECM components and activate MMP13, thereby inducing joint inflammation, chondrocyte apoptosis, and cartilage destruction (133)

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Similar results were observed with sulfasalazine (SSZ), an FDA-approved drug with ferroptosis-inducing activity

reviewed in Hay 55 ) that normally activates the transcription of important autophagy genes, such as BNIP3 (B-cell lymphoma 2 (Bcl-2)/adenovirus E1B 19 kDa interacting protein 3) and LC3 genes