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Comparison of long-term analgesic actions evoked by internalizing and non-internalizing DOR agonists has confirmed that similar to what was observed for MORs, both types of ligands induce tolerance after repeated administration [12, 86]

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Inflammation & cytoprotection (preclinical): BPC-157 shows gastroprotective and anti-inflammatory effects, and thymosin pathways are linked to reduced inflammation, in animal models [11]