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Cognitive dysfunction in systemic lupus erythematosus: How do we advance our understanding

doi: 10.3389/fpls.2025.1694779 Received 28 August 2025 Accepted 14 October 2025 Published 17 November 2025 Volume 16 - 2025 Edited by Saif Ali, CAB International, Pakistan Reviewed by Imran Ul Haq, University of Agriculture, Faisalabad, Pakistan Ali Hassan, Hubei University, China Muhammad Faisal, University of Agriculture, Pakistan Updates Copyright 2025 Umer, Naseer, Mubeen, Iftikhar, Umer, Akram, Altaf, Ibrahim, Ahmed and Duan

reads were trimmed using TrimGalore (48) and aligned to Ensemble hg38 using STAR (49)

The default settings for the SZMAP and Gameplan applications were used in all the calculations

To assess whether incorporating a second variable (ferroptosis genes) into the univariate model with EZH2 improved the models fit, we performed likelihood-ratio tests