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Glutathione peroxidase 4 (GPX4) is an endogenous suppressor of ferroptosis that limits peroxidation by catalyzing the glutathione (GSH)-dependent reduction of lipid hydroperoxides to lipid alcohols (LOH) and water (H 2 O) 22

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Clinical experience from practitioners treating MCAS and histamine intolerance adds human evidence, though formal clinical trials for allergic conditions specifically are still needed