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Supplementary information This file contains a Supplementary Discussion

According to age stratification, we found that there were significant differences in autophagy intensity and Pfirrmann classification

Optional NAD+ plus glutathione IV infusion before surgery and within the first week after

We use a baby needle, smaller than many acupuncture needles used in our own clinic

Acknowledgements This work was supported by NIH grant R01 CA79882 to JMS from the National Cancer Institute and by a Predoctoral Fellowship in Pharmacology by Pharmaceutical Research and Manufacturers of America Foundation awarded to Austin M Dulak