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The expression of CD79A, a component of the B-cell receptor, increased in expression with increasing emphysema severity (Figure 2b), and the expression of ACVRL1 (also known as activin-like kinase I), a receptor in the TGF pathway, decreased in expression with increasing emphysema severity (Figure 2c)

The PRISMA checklist has been included as Supplement Table 1

Detoxification: Unlike cyanocobalamin, which contains a cyanide molecule that must be detoxified and excreted by the body, Methylcobalamin does not pose this additional burden on the detoxification systems

doi:10.1007/s00018-007-7398-y Garattini E, Fratelli M, Terao M (2009) The mammalian aldehyde oxidase gene family

Burial was at Elm Springs Cemetery