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Bisubstrate inhibitors of nicotinamide N -methyltransferase (NNMT) with enhanced activity

Ghareeb H, Metanis N

Febs j 283, 26402652

This result was confirmed both by microscopic findings, in which vessel dilation, mucosal inflammation, and dilation of serous gland ducts were markedly reduced in mice treated with quercetin or topical nasal steroids compared to the control group, and by histopathological data that showed increased expression of Cyclooxygenase (COX)-2 and vasoactive intestinal polypeptide (VIP) in the control group

Sample size with sufficient power was determined via a small-scale pilot study for sarcomere number, length, and width, as well as thin filaments between mock knockdown, mock rescue, and FHOD3L WT rescue followed by inputting averages of the treatments on Each well was treated as a 1616 grid of 40X magnification fields of view