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These findings suggest that gut redox homeostasis is a key beneficiary of the restorative processes associated with sleep but that the gut may also actively mediate the systemic effects of sleep, including on longevity and aging (Vaccaro et al., 2020)

Mar 2004;43(3):162-5

Glucose-6-phosphate dehydrogenase ( G6pdx ), the rate-limiting enzyme of the pentose phosphate pathway and critical generator of NAPDH, was identified by ChIP sequencing to be an NRF2 target gene in diethyl maleate-treated mouse liver and hepatoma cells (54)

The Institute for Functional Medicine defines Functional Medicine as a personalized, systems-oriented model that empowers patients and practitioners to achieve the highest expression of health by working in collaboration to address the underlying causes of disease. Functional medicine is not alternativeits integrative, evidence-based, and science-based

The presence and absence of these insertions and deletions in different sequences match well with the results of single nucleotide variant based analyses (e.g., the insertions and deletions fit well with the single nucleotide-based phylogenetic trees, data not shown)