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The rate of permeation mainly indicates whether the compound crosses the BBB and how fast this process is

Mitochondrial dysfunction can also be a result of oxidative stress occurring in neurons, microglia, and astrocytes [6,26,28,30]

5 Impaired neurogenesis and synaptic plasticity The hippocampus is a critical brain region for learning and memory, and particularly vulnerable to paclitaxel-induced toxicity (Murillo et al., 2023)