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The amount of DDA was found an important parameter as low levels fail to induce a complete phase transfer where at high levels the formation of undesired stable emulsions was observed with dependence on the used organic solvent (details are available in Fig

Meyer et al., 2018)

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If you are interested in the details behind what we have just discussed: First, sulfonamide antibiotics have a N4 arylamine group, which is an NH group attached to an aromatic group. Second, they have an N1 group, which is a 5-6 membered heterocyclic ring that contains one or more nitrogen within the ring. These key differences are highlighted in the picture below

It assures that patients make informed decisions about their healthcare options