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In Phase 1 detoxification, liver enzymes (primarily the cytochrome P450 family) process these toxins, often making them even more reactive and dangerous in the short term

It can inhibit adipogenesis in murine preadipocytes by interfering with the Wnt/-catenin pathway, while promoting it in human mesenchymal stem cells by diverting cell fate from osteogenesis (91)

However, efficacy is variable, adverse effects can be substantial, and relapse rates remain high (Yiu et al., 2024)

Furthermore, the NAC treatment significantly upregulated the relative levels of SCX, TNC, TNMD and COLIA1 protein expression in TSPCs and the tendon tissues of rats after tendon injury, highlighting the importance of NAC treatment in promoting the tenogenic differentiation of TSPCs in vitro and in vivo

Brain 72 , 373381 (1949)