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doi: 10.1126/scisignal.3132pe24 143 BoschelliDH

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In 1956, Denham Harman proposed the free radical theory of aging, arguing that degenerative changes during aging are mediated by the harmful effects of free radicals generated during normal cellular metabolism

Patients were assessed additionally regarding cognitive functions and filled-in questionnaires regarding sleep quality, daily sleepiness, and quality of life, using the Montreal Cognitive Assessment, MoCA 38 , the Parkinson's disease sleep scale (PDSS2) 39 , the Epworth Sleepiness Scale (ESS) 40 and the Parkinsons Disease Questionnaire (PDQ-39) 41 , respectively

Eur J Immunol 28:41624169 Sparkman NL, Buchanan JB, Heyen JR, Chen J, Beverly JL, Johnson RW (2006) Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers