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doi:10.1111/ene.15435 47

Dit anion splitst dan snel een disulfide binding (Cys 58 - Cys 63 ) waarbij Cys 63 vrij komt, dat vervolgens als nucleofiel reageert met de dichtstbijzijnde sulfide eenheid in het GSSG molecule (bevorderd door His 467 ) tot een gemengde disulfide binding (GS-Cys 58 ) en een GS anion

Pediatric patients less than 2 years of age, including neonates from 28 to 40 weeks gestational age at birth, were randomized to receive opioid plus acetaminophen or opioid plus placebo