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In neurons, expression of phosphorylation deficient form of CLIMP63 results in fewer proximal dendritic branches, while expression of phosphomimetic form or RNAi mediated knockdown promotes dendritic branching (Cui-Wang et al., Cul7 Fbxw8 ubiquitin ligase Fbxw8 is an F-box protein that assembles with the scaffold protein, Cul7

While the potential of Dihexa in improving stroke recovery is promising, it is important to note that further research is necessary to validate its efficacy and safety in human subjects

demonstrated in a PD rat model that VNS increased NE in the LC and significantly inhibited the activation of microglia and astrocytes induced by 6-Hydroxydopamine (6-OHDA), exerting a protective effect on DA neurons in the SN (110)

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