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The small-molecule iron transport inhibitor ferristatin/NSC306711 promotes degradation of the transferrin receptor

As a result, puerarin can inhibit LPS-induced breast cancer cell migration, invasion, and adhesion (138)

Paradoxically, both mTORC1 inhibition by rapamycin and silencing of Rheb reverse this effect in TSC2 -null cells, sending TFEB back to the cytoplasm and promoting its re-phosphorylation by mTORC1, for which the latter event appears to be controlled by the Rags [101]

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