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It exerts anticancer effects by modulating various apoptosis-related proteins, cell cycle regulators, protein kinases, transcriptional factors, cytokines, and growth receptors in cancer cells [28]

However, research shows that neurological and psychiatric symptoms can occur even with levels under 500 pg/mL (OLeary & Samman, 2010)

Analysis of breast tumor tissues confirmed the increased level of DNA damage, most likely attributed to the formation of 4-hydroxy estradiol (4-OHE) mediated by cytochrome P450, which in turn can trigger the formation of ROS such as H 2 O 2 that are catalytically decomposed to OH radicals via the iron-Fenton reaction

[DOI] [PubMed] [Google Scholar] 197.Yu Y., Yang F.-H., Zhang W.-T., Guo Y.-D., Ye L., Yao X.-D

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