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doi:10.1523/JNEUROSCI.1860-14.2014

4a and c), while cells treated with B2M-CuS NPs were intensely fluorescent, indicating substantial intracellular ROS formation

Ann Shippy Yes

Specifically, we detected higher expression of the ferritinophagy mediator NCOA4 (encoding nuclear receptor coactivator 4, which binds to ferritin and delivers it to the autophagy-lysosomal machinery) 63 , as well as MCOLN1 (encoding mucolipin transient receptor potential cation channel, also known as TRPML1), which transports iron from the lysosomes to the cytoplasm 67 and is required for lysosomal biogenesis 68 (Fig