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Therefore, it has been observed that the antioxidant capacity found in the cellular matrix may become reduced in critical clinical conditions, including septic shock, cardiac bypass surgery, and reperfusion injury after organ transplantation, and renal dialysis [216]

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The same study revealed that inhibiting HMGB1 down-regulated Bcl-2 and MMP-2 but up-regulated Bax in gastric cancer cells [163]

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