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The pharmacokinetic rationale is questionable given the 5-day half-life, but some users report better side effect tolerance with split dosing

[2] Intravenous Glutathione: A Separate Consideration Patients receiving high-dose IV glutathione infusions (doses of 600 to 2,400 mg) for skin-lightening, chronic fatigue, or functional medicine protocols may reach transiently higher plasma glutathione concentrations than oral supplementation produces

Safety Profile Moderately toxic by intravenous route

A 70kg participant and a 120kg participant both received the same milligram dose at each escalation step

Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight