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Based on these findings, it could be hypothesized that TCPOBOP initially protects by promoting CAR activity but later contributes to increased lethality

Often, patients are in an urgent or desperate situation upon initial presentation or at the time of recurrence of disease, e.g., superior vena cava syndrome ( In response to the dismal prognosis of SCLC, innumerable drugs have been tested, several drugs have earned NCCN compendium listing, and some drugs are FDA-approved

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*Correspondence: Richard Eugene Frye, Arkansas Childrens Hospital Research Institute, Slot 512-41B, 13 Childrens Way, Little Rock, AR 72202, USA e-mail: [email protected] This article was submitted to Child and Neurodevelopmental Psychiatry, a section of the journal Frontiers in Pediatrics