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Supplementation with external antioxidants is a crucial strategy to combat oxidative stress, especially in AD patients, enhancing their ability to manage oxidative stress (27)

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We subsequently determined whether IPA enhances ISC proliferation in organoid assays, determining that no differences in colonic organoid formation and development were present between Veh- and IPA-treated mice at D0, indicating that IPA does not affect ISC proliferation ex vivo in the absence of DSS-induced injury