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When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways

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Conclusions In summary, Schwann-like cells converted from GMSCs retained potent immunomodulatory functions to promote pro-regenerative (M2) macrophage polarization and suppress pro-inflammatory (M1) macrophage activation

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I think that they are hoping that giving large doses of oral B12 will give some passive absorbtion, which will keep levels up