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[DOI] [PubMed] [Google Scholar] 53.Qiu Z., Zhou J., Zhang C., Cheng Y., Hu J., Zheng G

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When the intestinal epithelial barrier function is impaired, under lipopolysaccharide stimulation, nuclear factor kappa B (NF-kB) translocates from the cytoplasm to the nucleus, and stimulates dendritic cells and macrophages to produce pro-inflammatory cytokines and mediators, such as cyclooxygenase-2, TNF- , inducible nitric oxide synthase, and IL-6, which regulate intestinal and systemic inflammation (92)