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60,61 Hyperactivation of the phosphoinositide 3-kinase and AKT (PI3KAKT) pathway has also been implicated in the rewiring of specific metabolic processes, including increased glucose uptake through stabilisation of glucose transporter 1 (GLUT1), enhanced glutamine anaplerosis via activation of glutamate pyruvate transaminase 2 (GPT2) and remodelling of the cellular lipidome

Values intermediate of those set forth herein are also intended to be within the scope of the present invention and a preferred binding affinity can be indicated as a range of affinities, for example, 10 -6 M to 10 -11 M, preferably 10 -7 M or 10 -8 M to 10 -10 M

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The two names will remain interchangeable during a three-year transition period

doi: 10.1126/scitranslmed.3001006 80