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MARCH5-dependent NLRP3 ubiquitination is required for mitochondrial NLRP3-NEK7 complex formation and NLRP3 inflammasome activation

Concurrently, pivotal metabolic enzymes within the amino acid synthesis pathway, including glutamate-oxaloacetate transaminase 1 (GOT1), glutamate-pyruvate transaminase 2 (GPT2), pyrrolidine-5-carboxylic acid reductase 1 (PYCR1), and phosphoserine aminotransferase 1 (PSAT1), demonstrated increased expression [214]

Tran, N., Garcia, T., M Aniqa, Ali, S., Ally, A., & SM Nauli

Overall, ferroptosis acts as a triggering factor of inflammation, affecting the bodys immune regulatory system, promoting iron ion-induced lipid peroxidation, and inducing osteoclast differentiation while inhibiting osteoblast proliferation, leading to cartilage destruction and bone erosion

Cells 8(8):80 Kuo TC, Chen CK, Hua KT et al (2016) Glutaminase 2 stabilizes Dicer to repress Snail and metastasis in hepatocellular carcinoma cells