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Third, translational gaps between preclinical models and clinical practice are prominent: most therapeutic candidates (e.g., natural products and repurposed drugs) have only been validated in rodent models, with limited data on human renal tissue responses, optimal dosing windows, or potential drugdrug interactions in clinical settings (e.g., in patients undergoing kidney transplantation or cardiovascular surgery)

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It prolonged the damage caused by drinking too much, and it was also extremely painful for the addicted person

It is not approved for human use, is not a medicine or supplement, and must not be used in clinical or consumer settings