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Epigenetics in platelet hyperactivity Epigenetic changes may influence the generation and release into the circulation of proteins involved in blood coagulation and fibrinolysis

Hematological signs include megaloblastic anemia or pancytopenia

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CAR T cells engineered to be resistant to immunosuppression (armored CARs) may be genetically modified to no longer express various immune checkpoint molecules (for example, cytotoxic T lymphocyte-associated antigen 4 (CTLA4) or programmed cell death protein 1 (PD1)), with an immune checkpoint switch receptor, or may be administered with a monoclonal antibody that blocks immune checkpoint signaling