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In the central nervous system (CNS), both cell replacement and tissue engineering strategies are being vigorously pursued to facilitate regeneration of native tissue and/or to directly restore lost function based on permanent structural integration

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Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]