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In addition to physical tissue damage, such as axonal injuries, contusions, and haemorrhages, TBI interferes with brain functioning, impacting cognition, decision-making, memory, attention, and speech capabilities

Arking, R.H

The fact that mitochondria promotes metabolic plasticity associated with resistance to therapy and the existence of several drug able regulators, proposes this events as promising therapeutic targets in cancer

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In a transgenic mouse model of mutant alpha-synuclein (A53T), experiments showed that alpha-synuclein accumulation in astrocytes affected glutamate transport, triggering a rise of extracellular glutamatergic concentrations and excitotoxicity, which further exacerbated damage to dopaminergic neurons (Gu et al., 2010)