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TJ paracellular barrier function is based on two independently regulated routes 37 , namely the pore pathway: a highly selective route for the flux of ions and water, that is regulated by claudins

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Second, long-term safety is a critical consideration for any potential AD treatment, and while our short-term safety evaluation did not reveal any significant adverse effects associated with (-)-Vestitol and Salviolone administration, it is crucial to acknowledge that these findings do not guarantee long-term safety when used chronically for AD treatment

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& Kissow, H