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Studies have found that the methylation of CD44 is correlated with progression and metastasis in prostate cancer (271,272) and Yegnasubramanian et al (273) indicated that the hypermethylation of PTGS2 CpG islands predicted an increased risk of prostate cancer recurrence in 2004

Biomaterials 301 , 122284

Research indicates that sulforaphane imparts pleiotropic effects on cancer, affecting it at many stages from formation to progression [278]

Structurally, it features a protonated -amino group (NH) and a deprotonated -carboxyl group (COO) at physiological pH, along with a polar carboxamide side chain, classifying it as a polar, aliphatic AA (de Souza Lacerda et al