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Clinical studies have shown no major side effects, though mild bloating or nausea can occur if taken on a very full stomach

Also, pyruvate dehydrogenase kinase isoenzyme-4 encodes pyruvate dehydrogenase complex (PDK)

The rationale is mechanistic: the two compounds operate through distinct but non-overlapping pathways, with tissue targets that complement rather than duplicate each other

Ascorbic acid (vitamin C) and -tocopherol (vitamin E) obtained mostly from diet are also important non-enzymatic erythrocyte antioxidants [19]

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