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The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles

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In fact, fragment screening is now well-established as a powerful approach to early drug discovery since it gives the unique opportunity to probe protein surfaces with limited collections of small molecules (150250 Da) covering a large chemical space ( 2 Experimental Methods 2.1 Protein Production and Crystallization TR from L