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The crystal structure of the wild-type AR illustrated the reason why the LxxLL motifs of typical NR coactivators fail to hydrogen bond with Glu897 of H12 and make fewer and less optimized hydrophobic contacts with the AF2 pocket compared with FxxLF-containing peptides, explaining the lower affinity of AF2 for the LXXLL-containing p160-type coactivators 82

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Recombinant mBNIP3-M and recombinant mBAX-His were used at concentrations of 5 g ml 1 and 1 g ml 1

Each sample was analyzed for estimating the effect of Vitamin-U on a High-Fat Diet and nicotine induced Non-Alcoholic Fatty Liver Disease in rats