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(ref) Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JS

Tight junctions are the fundamental for BBB integrity with very low paracellular leakage, and are critical for controlling hydrophilic molecules [10]

10 ul of each drug solution was added to 90 ul of the rat blood serum samples and at specific time intervals the researchers terminated metabolism by adding 1 ml of ACN and acetic acid in order to precipitate the proteins which were then removed after overnight refrigeration followed by centrifugation

Pharmacodynamic and pharmacokinetic parameters were dose-dependent

Additionally, BPC 157 did not demonstrate any genetic or embryo-fetal toxicity during safety evaluations, ensuring that it does not pose significant risks to genetic integrity or fetal development