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The disease is progressive, and if left untreated, can cause liver disease, brain injury, and premature death

It is unclear whether loss of GPx-1 is causative or whether it occurs secondary to cellular transformation to promote subsequent tumor growth (presumably by enhanced hydrogen peroxide-mediated growth factor responses)

Abbreviations ATP: Adenosine triphosphate c-Met (HGFR): Hepatocyte growth factor receptor EGFR: Epidermal growth factor receptor EMT: Epithelial mesenchymal transition HGF: Hepatocyte growth factor MAPK: Mitogen-activated protein kinase MET: Mesenchymal-to-epithelial transition MM: Malignant melanoma NF-B: Nuclear factor-B NK cells: Natural killer cells PDGFR: Platelet-derived growth factor receptor PI3K: Phosphatidylinositol-3 kinase PTKs: Protein tyrosine kinases Rel3 (EGFP-A375/Rel3): Hypermetastatic human malignant melanoma cell line derived from EGFP-A375 RTKs: Receptor tyrosine kinases TGF-: Transforming growth factor-Beta References Lambert AW, Pattabiraman DR, Weinberg RA

Under physiological conditions, the Nrf2 pathway acts as a primary defense mechanism by inducing antioxidant enzymes such as HO-1, SOD, and catalase

2019, 2009) in accordance with the University of South Carolina Institutional Animal Care and Use Committee