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The engineered CAR used the scFv regions previously described 42,54 but with the CD8a hinge/TM domains and 4-1BB costimulatory domain

doi: 10.1096/fj.08-108274 255 LiSSunRChenYWeiHTianZ

Stem cell research is ongoing to determine whether these treatments can safely and effectively slow or halt the progression of ALS, with early results showing promise but also highlighting the need for more research to overcome these challenges

Ye L, Park JJ, Peng L, Yang Q, Chow RD, Dong MB, Lam SZ, Guo J, Tang E, Zhang Y, Wang G, Dai X, Du Y, Kim HR, Cao H, Errami Y, Clark P, Bersenev A, Montgomery RR, Chen S

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