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Increased expression levels of xCT signify that cancer cells rely on extracellular cystine, as it is upregulated in CSCs in several solid tumors, including breast cancer (43)

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p38 MAPK activation and function following osmotic shock of erythrocytes

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Honokiol also inhibited caspase-1 activation, and apoptosis speck-like protein oligomerization, suggesting dual inhibition of NLRP3 inflammasome priming and activation processes through the modulation of the SLC3A2/L-leucine/mTORC1/NLRP3 pathways [490]